Paper Title:
Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate
  Abstract

Hydroxyapatite-tricalcium phosphate (HA-TCP) is a new kind of material which shows good biocompatibility, biological degradability, and porosity. This study aimed to determine the effectiveness of HA-TCP as a bone tissue engineering scaffold. In this study, critical size cranial defects were reconstructed with compounds of autogenous bone marrow stromal cells (BMSCs) and HA-TCP. The resulting grafts were examined by X-ray, histological examination, semi-quantitative analysis of osteogenesis, immunochemical examination (collagen type I and III), scanning electron microscopy and transmission electron microscopy. The results showed that HA-TCP is a good bone tissue engineering scaffold and BMSCs/HA-TCP is a promising technique for reconstruction of bone defects.

  Info
Periodical
Key Engineering Materials (Volumes 368-372)
Edited by
Wei Pan and Jianghong Gong
Pages
1235-1237
DOI
10.4028/www.scientific.net/KEM.368-372.1235
Citation
L. Liu, R. L. Chen, Y. F. Lin, W. D. Tian, S. W. Li, "Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate", Key Engineering Materials, Vols. 368-372, pp. 1235-1237, 2008
Online since
February 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: C.S. Lim, S.G. Kim, Sung Chul Lim
Abstract:We evaluated the bone healing effect of grafting with synthetic β-tricalcium phosphate (β-TCP; Cerasorb®), bovine-derived hydroxyapatite...
1261
Authors: Monica Calasans-Maia, Antonella M. Rossi, Eliane Pedra Dias, Silvia R. A. Santos, Fabio Áscoli, José Mauro Granjeiro
Abstract:The study was carried out aiming the evaluation of the effect of hydroxyapatite (HA) and zinc-substituted hydroxyapatite (ZnHA) on osseous...
1269
Authors: G.V.O. Fernandes, Monica Calasans-Maia, F.F. Mitri, Vagner Gonçalves Bernardo, Antonella M. Rossi, G.D.S. Almeida, José Mauro Granjeiro
Abstract:Biomaterials for treatment of bone defects have been studied for a long time. Alloplastic materials, mainly hydroxyapatite (HA), are under...
15
Authors: Cornelia Ganz, W. Xu, G. Holzhüter, W. Götz, B. Vollmar, Th. Gerber
Abstract:Various bone graft substitutes were used in clinical practise in the treatment of bone defects after trauma or osteoporosis. Many synthetic...
732
Authors: Debora Helena Yassuda-Mattos, Neusa Motta de Freitas Costa, Débora dos Santos Tavares, G.V.O. Fernandes, A. Alves, José Mauro Granjeiro, Gloria Dulce de Almeida Soares
Abstract:Porous granules were obtained through a route using a mixture of calcium phosphate powder with sodium alginate solution. The sintered β-TCP...
263