Twist drill is widely used in hole-making process in industries, due their low production cost and ease of regrinding after wear. However, drilling of fiber reinforced plastics with twist drill often results in defects and damages, such as delamination, debonding, spalling and fiber pullout. The chisel edge of twist drill is the mainly influence for the thrust force and the hole quality in drilling carbon fiber reinforced plastic (CFRP) laminates. Pre-drilled pilot hole or reduce chisel edge can eliminate the threat for twist drill in drilling induced-delamination. Drilling-induced thrust force was selected as quality character factors to optimize the drilling parameters (drill type, feed rate and spindle speed) to get the smaller the better machining characteristics by Taguchi method. The results show that the feed rate and drill type are the most significant factor affecting the induced-thrust in drilling CFRP laminates.