A new 5-degrees-of-freedom hybrid kinematic machine(HKM) consisting of a 4-degrees-of-freedom PTS-based parallel kinematics platform with center constraint branch and a serial X axis is developed. The will-be-machined workpiece is mounted on the platform and the spindle movement is driven by the X axis. This new HKM is very different from a conventional serial-type machine. Therefore, a special algorithm that can transfer the cutter location data (CL-data) into machine specific NC commands is essential for the applications of the PTS-X based HKM in real machining of the workpiece with the complicated surface. The workpiece’s location approach on the platform and the orientation transformation of the moving platform relative to the machine coordination system are investigated.