Paper Title:
A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration
  Abstract

Historically the function of biomaterials has been to replace diseased, damaged and aged tissues. First generation biomaterials, including bio ceramics, were selected to be as inert as possible in order to minimize the thickness of interfacial scar tissue. Bioactive glasses provided an alternative from the 1970’s onward; second generation bioactive bonding of implants with tissues and no interfacial scar tissue. This chapter reviews the discovery that controlled release of biologically active Ca and Si ions from bioactive glasses leads to the up-regulation and activation of seven families of genes in osteoprogenitor cells that give rise to rapid bone regeneration. This finding offers the possibility of creating a new generation of gene activating bioceramics designed specially for tissue engineering and in situ regeneration of tissues.

  Info
Periodical
Edited by
Maria Vallet-Regí
Pages
151-166
DOI
10.4028/www.scientific.net/KEM.377.151
Citation
L. L. Hench, J. M. Polak, "A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration", Key Engineering Materials, Vol. 377, pp. 151-166, 2008
Online since
March 2008
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Price
$32.00
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