Paper Title:
Upgrading Calcium Phosphate Scaffolds for Tissue Engineering Applications
  Abstract

The research on ceramic scaffolds for bone tissue engineering is, nowadays, one of the newest and most attractive topics in the field of materials for biomedical applications. These scaffolds are aimed to provide supporting or even enhance the reparative capacity of body. Biphasic calcium phosphates (BCPs) and silicon doped BCP are very interesting candidates to be used as materials for scaffolds fabrication in bone tissue engineering. BCPs and silicon doped BCP consist of a mixture of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) or HA and α-tricalcium phosphate (α-TCP), respectively. For the regenerative purposes BCPs show better performance than HA because of the higher solubility of β-TCP compound, which facilitate the subsequent bone ingrowth in the implant. On the other, silicon doped BCP involve silicon that substituted into the apaptite crystal lattice for phosphorous with the subsequent charge imbalance. HA/α-TCP based bioceramics exhibits an important improvement of the bioactive behaviour with respect to non-substituted apatites. This work reviews the procedures to synthesise and fabricate scaffolds based on HA/β-TCP and silicon stabilised HA/α-TCP. Special attraction has been paid in the different synthesis methods and to the shaping of final scaffolds. By knowing the scaffold features at the crystallinity and macrostuctural level, the biocompatibility and clinical performance can be better understood, which will be also considered in this review.

  Info
Periodical
Edited by
Maria Vallet-Regí
Pages
19-42
DOI
10.4028/www.scientific.net/KEM.377.19
Citation
S. Sánchez-Salcedo, D. Arcos, M. Vallet-Regí, "Upgrading Calcium Phosphate Scaffolds for Tissue Engineering Applications", Key Engineering Materials, Vol. 377, pp. 19-42, 2008
Online since
March 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Shu Jie Lin, Racquel Z. LeGeros, Ramin Rohanizadeh, Dindo Q. Mijares, John P. LeGeros
473
Authors: G. Daculsi
Abstract:The development of calcium phosphate ceramics and other related biomaterials for bone graft involved a better control of the process of...
9
Authors: L. Bakhtiari, Hamid Reza Rezaie, S.M. Hosseinalipour, Mohammad A. Shokrgozar
Abstract:A new porous structure as a bone tissue engineering scaffold was developed by a freeze-drying method. The porous nanocomposite was prepared...
67
Authors: Ho Yeon Song, Young Hee Kim, Jyoti M. Anirban, In Seon Byun, Kyung A Kwak, Byong Taek Lee
Abstract:Calcium phosphate ceramics such as hydroxy apatite (HA), β-tricalcium phosphate (β-TCP) and bicalcium phosphate (BCP) have been used as a...
2065
Authors: Min Sung Kim, Dong Woo Jang, Young Ki Min, Hun Mo Yang, Ho Yeon Song, Byong Taek Lee
Abstract:Calcium phosphate bone substitutes are widely used for providing support for the in-growth of hard tissue in various medical applications...
2245