In this technical manuscript the cyclic stress amplitude controlled fatigue properties and fracture behavior of an emerging titanium alloy (referred to by its designation as ATI 425TM by the manufacturer) is presented and discussed. The alloy was provided as rod stock in the fully annealed condition. Test specimens of the as-received alloy were cyclically deformed under total stress amplitude control at two different stress ratios (R = 0.1 and R = 0.3) with the purpose of establishing the conjoint and mutually interactive influences of magnitude of cyclic stress, load ratio and intrinsic microstructural effects on cyclic fatigue life, final fracture behavior and viable mechanisms governing failure at the microscopic level. The high cycle fatigue resistance of this titanium alloy is described in terms of maximum stress, load ratio, and maximum elastic strain. The final fracture behavior of the alloy under cyclic loading conditions is discussed in light of the mutually interactive influences of intrinsic microstructural features, magnitude of cyclic stress, load ratio and resultant fatigue life.