Cylindrical specimens of cast polycrystalline nickel base superalloy Inconel 738LC were cyclically strained under total strain control at 23 and 800 °C to fracture. Cyclic hardening/softening curves, cyclic stress-strain curves, and fatigue life curves were obtained at both temperatures. Surface relief was studied in specimens fatigued to failure using scanning electron microscopy. Cyclic hardening/softening behaviour depends both on temperature and strain amplitude. Low amplitude straining was characterized by saturation of the stress amplitude. In high amplitude straining a pronounced hardening was found which was followed by saturation at room temperature and by cyclic softening at 800 °C. The cyclic stress-strain curves can be fitted by power law. They are shifted to lower stresses with increasing temperature. Fatigue life curves can be approximated by the Manson- Coffin and Basquin laws. The Manson-Coffin and Basquin curves are shifted to lower lives with increasing temperature. Slip markings were detected on specimen surface at all test temperatures. When temperature grows the density of slip markings is reduced.