TiO2 has some unique photocatalytic functions and some of them have been utilized industrially, and further functional enhancement and performance enhancement of TiO2 have been required. Under such circumstances, this study aims to clarify the influence of surface topography on the photocatalytic reaction of TiO2 film surface. As the first step, the optimum mixing ratio in film preparation by using TiO2 powder was examined and the films with several kinds of surface roughnesses were prepared. And, the influence of surface topography on the wettabilty, which is one of the photocatalytic functions of TiO2 was evaluated. As a result, it was confirmed that the wettability of TiO2 films could be improved by increasing both the surface roughness and actual surface area under the ultraviolet rays irradiation environment.