Paper Title:
Release Properties and Acute Biosecurity Determination of Collagen-Polyvinylpyrrolidone Loaded in Ordered Mesoporous Silica
  Abstract

Mesoporous silica type SBA-15 has high specific surface area, well ordered pores and renders larges volumes, reasons for its potential use in controlled drug delivery system; in addition its non toxic nature and good biocompatibility. The aim of this work is to determine the feasibility of loading collagen-polyvinylpyrrolidone (collagen-PVP) molecules into Biocompatible Nanostructured Ordered Mesoporous Silica (BINOM-Silica). Collagen-PVP has several medical uses, such as fibrolytic activity and tissue regeneration. Therefore, this BINOM-Silica/collagen- PVP material could be used as drug delivery system for hypertrophic scarring. Different BINOMSilica materials were prepared using a triblock copolymer in an acid medium and stabilized at 557°C and later, collagen-PVP was loaded into the material. The small angle powder X-ray diffraction patterns of BINOM-Silica materials, in some cases, indicate the existence of a high degree of hexagonal mesoscopic organization. The nitrogen sorption isotherms are type IV typical of mesoporous materials with large surface area. In vitro release of collagen-PVP was carried out by mean of UV/VIS spectroscopy. The cumulative release profiles of Silica-collagen PVP in distilled water indicate a two step release, an initial fast release and a relatively slow subsequent release, indicating an appropriate delivery of collagen-PVP for therapeutic administration. BINOMSilica/ collagen-PVP intradermical administration stimulated inflammatory infiltrates only in an acute phase (day 3), demonstrating that silica materials and their combination with chemical and biological drugs could be safe for therapeutics. The absence of inflammatory infiltrates at day 7 suggested an appropriate integration of BINOM-Silica/collagen-PVP into the tissue. These results indicate that we obtained biocompatible nanostructured ordered mesoporous silica materials useful for delivery systems.

  Info
Periodical
Edited by
Luis Esquivias
Pages
169-184
DOI
10.4028/www.scientific.net/KEM.391.169
Citation
T. López, F. E. Krötzsch, E. Ortiz Islas, M. Alvarez Lemus, E. Balsadella, J.M. Martínez-Blanes, J. A. Odriozola, "Release Properties and Acute Biosecurity Determination of Collagen-Polyvinylpyrrolidone Loaded in Ordered Mesoporous Silica", Key Engineering Materials, Vol. 391, pp. 169-184, 2009
Online since
October 2008
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Authors: Cong Guo, Mou Zheng Liu, Wen Zhi Li
Chapter 2: Electrochemistry, Chemical Materials and Technologies
Abstract:A flexible, controllable and facile synthesis route was presented in the synthesis of spherical particles of mesoporous SBA-15 with diameter...
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