Release Properties and Acute Biosecurity Determination of Collagen-Polyvinylpyrrolidone Loaded in Ordered Mesoporous Silica |
| Journal |
Key Engineering Materials (Volume 391) |
| Volume |
Progress in Sol-Gel Production |
| Edited by |
Luis Esquivias |
| Pages |
169-184 |
| DOI |
10.4028/www.scientific.net/KEM.391.169 |
| Online since |
October, 2008 |
| Authors |
T. López,
E. Krötzsch,
E. Ortiz Islas,
M. Alvarez Lemus,
E. Balsadella,
J.Ma Martínez-Blanes,
José Antonio Odriozola
|
| Keywords |
BINOM-Silica Materials, Collagen-Polyvinylpyrrolidone, Drug Release |
| Abstract |
Mesoporous silica type SBA-15 has high specific surface area, well ordered pores and renders
larges volumes, reasons for its potential use in controlled drug delivery system; in addition its non
toxic nature and good biocompatibility. The aim of this work is to determine the feasibility of
loading collagen-polyvinylpyrrolidone (collagen-PVP) molecules into Biocompatible
Nanostructured Ordered Mesoporous Silica (BINOM-Silica). Collagen-PVP has several medical
uses, such as fibrolytic activity and tissue regeneration. Therefore, this BINOM-Silica/collagen-
PVP material could be used as drug delivery system for hypertrophic scarring. Different BINOMSilica
materials were prepared using a triblock copolymer in an acid medium and stabilized at
557°C and later, collagen-PVP was loaded into the material. The small angle powder X-ray
diffraction patterns of BINOM-Silica materials, in some cases, indicate the existence of a high
degree of hexagonal mesoscopic organization. The nitrogen sorption isotherms are type IV typical
of mesoporous materials with large surface area. In vitro release of collagen-PVP was carried out by
mean of UV/VIS spectroscopy. The cumulative release profiles of Silica-collagen PVP in distilled
water indicate a two step release, an initial fast release and a relatively slow subsequent release,
indicating an appropriate delivery of collagen-PVP for therapeutic administration. BINOMSilica/
collagen-PVP intradermical administration stimulated inflammatory infiltrates only in an
acute phase (day 3), demonstrating that silica materials and their combination with chemical and
biological drugs could be safe for therapeutics. The absence of inflammatory infiltrates at day 7
suggested an appropriate integration of BINOM-Silica/collagen-PVP into the tissue. These results
indicate that we obtained biocompatible nanostructured ordered mesoporous silica materials useful
for delivery systems. |
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