A parameter equation based on cutting edge of ball-end mill is set up by analyzing the parameters of ball-end mill influence the milling force in virtual NC milling process. The relationship among elemental cutting force, instantaneous radial chip thickness and cutting edge length is analyzed, and the dynamic milling force of ball-end mill at arbitrary feed direction is established. The milling force parameter model by quadratic regression equation in different cutting conditions is built. Through experiments in NC machining center and using orthogonal combination and principal components analysis, the regression coefficients are calculated. The correctness of milling force model is testified by experiments. All these can provide theoretical basis for physics modeling and simulation of virtual numerical control milling.