Paper Title:
Osteoconductivity of Hydrothermally Synthesized Beta-Tricalcium Phosphate Composed of Rod-Shaped Particles under Mechanical Unloading
  Abstract

Spherical beta-tricalcium phosphate (b-TCP) granules synthesized using a unique dropping slurry method expressed good osteoconductivity with prominent bone apposition and bioresorbability when implanted into the rat femur (Gonda et al., Key Eng. Mater. 361-363:1013-1016, 2008). The spherical b-TCP granules were implanted into the bone defect created in the distal end of the right femur of each 8-week-old female Wistar rat. To analyze performance of the spherical b-TCP granules as bone substitute in the bone with reduction in osteogenic potential, the right sciatic neurectomy was performed after implantation and the right hind limb was kept unloaded for 2 weeks before euthanization. Four weeks after implantation, some spherical b-TCP granules with resorption in part were surrounded by newly formed bone. Eight and 12 weeks after implantation, most of the residual b-TCP granules were embedded in newly formed bone, and total volume of the implant and newly formed bone was more than the other portions of the bone or the bone of control animals. Osteoclast activity in the implanted area was also higher than the other portions of the bone or the bone of control animals. Replacement of the intraosseous residual b-TCP granules for bone progressed at 12 weeks after implantation compared to those at 8 weeks after implantation. These data suggested that the spherical b-TCP granules stimulated osteogenesis and osteoclast activity of the unloaded bone.

  Info
Periodical
Key Engineering Materials (Volumes 396-398)
Main Theme
Edited by
Marcelo Prado and Cecília Zavaglia
Pages
253-256
DOI
10.4028/www.scientific.net/KEM.396-398.253
Citation
Y. Gonda, K. Ioku, T. Okuda, Y. Shibata, M. Kamitakahara, G. Kawachi, I. Yonezawa, H. Kurosawa, T. Ikeda, "Osteoconductivity of Hydrothermally Synthesized Beta-Tricalcium Phosphate Composed of Rod-Shaped Particles under Mechanical Unloading", Key Engineering Materials, Vols. 396-398, pp. 253-256, 2009
Online since
October 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: H. Teramoto, A. Kawai, S. Sugihara, A. Yoshida, Hisahiro Inoue
269
Authors: G. Daculsi, I. Khairoun, Racquel Z. LeGeros, Françoise Moreau, Paul Pilet, Xavier Bourges, Pierre Weiss, Olivier Gauthier
811
Authors: Clemencia Rodríguez, Alain Jean, Sylvia Mitja, G. Daculsi
Abstract:To overcome autograft use for dental implantation, it is important to prevent bone loss after tooth extraction or to restore alveolar bone...
1339
Authors: H. Valiense, G.V.O. Fernandes, B. Moura, J. Calasans-Maia, A. Alves, Antonella M. Rossi, J.M. Granjeiro, M. Calasans-Maia
Abstract:The objective of this study was to investigate the bone repair of carbonate apatite (cHA) in comparison to hydroxyapatite (HA, control...
258
Authors: Debora Helena Yassuda-Mattos, Neusa Motta de Freitas Costa, Débora dos Santos Tavares, G.V.O. Fernandes, A. Alves, José Mauro Granjeiro, Gloria Dulce de Almeida Soares
Abstract:Porous granules were obtained through a route using a mixture of calcium phosphate powder with sodium alginate solution. The sintered β-TCP...
263