Paper Title:
PLGA-Hydroxyapatite Composite Scaffolds for Osteoblastic-Like Cells
  Abstract

The aim of this work was to investigate the behaviour of rat calvarial osteoblastics cells on porous PLGA/HA composite scaffolds. Cells were submitted to cytotoxicity and cell adhesion assay. In addition, the cells morphology were observed by SEM, and the collagen synthesis measured by Sirius Red colorimetric method. The results showed that the material was not cytotoxic and hydroxyapatite improved cell adhesion. Osteoblastic cells could adhere and spread on the scaffolds as observed. After 14 days the presence of hydroxyapatite increased the synthesis of collagen. This study demonstrates that composite scaffolds presented better cellular responses compared to polymer scaffolds.

  Info
Periodical
Key Engineering Materials (Volumes 396-398)
Main Theme
Edited by
Marcelo Prado and Cecília Zavaglia
Pages
461-464
DOI
10.4028/www.scientific.net/KEM.396-398.461
Citation
A. Dutra Messias, A. Aragones, E. Aparecida de Rezende Duek, "PLGA-Hydroxyapatite Composite Scaffolds for Osteoblastic-Like Cells", Key Engineering Materials, Vols. 396-398, pp. 461-464, 2009
Online since
October 2008
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$32.00
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