Paper Title:
TTCP-DCPA Based Calcium Phosphate Cements Containing Hybrid Microparticles as Drug Carriers
  Abstract

In recent years, considerable attention has been focused on the development of new composite materials for application as drug delivery systems. In this field, calcium phosphate cements (CPCs) are often employed as support to delivery of drugs, but their behavior has some drawback related to the so-called burst effect. The aim of this work was to develop new CPCs formulations from synthesized tetracalcium phosphate (TTCP), dicalcium phosphate anhydrous TTCP and drug-containing hybrid microparticles (DCHM). The main function of these DCHM is providing nuclei of high concentration of drugs into the CPCs. The DCHM were synthesized via the sol-gel method from a bridged precursor of the type (H3CO)3 – Bridge – (OCH3)3 and aspirin (AS) as model drug. The inorganic polycondensation reached 89.5 % as calculated by 29Si NMR. The analysis by small angle X-ray scattering (SAXS) reveled a short range structural ordering in the DCHM at molecular level. Effective incorporation of AS inside the microspheres was detected by FTIR spectroscopy. In vitro tests of DCHM according to ISO 10993-5 revealed non-cytotoxic behavior. Four CPCs formulations containing 0, 1, 5 and 10 wt % of DCHM, were evaluated. The presence of DCHM did not modify neither the degree of conversion to low-crystallinity HA nor the measured setting times of the CPCs, however, the amount of incorporated microparticles considerably affected the degree of porosity (macropores of 200 µm) and interconnectivity of the cement matrix.

  Info
Periodical
Key Engineering Materials (Volumes 396-398)
Main Theme
Edited by
Marcelo Prado and Cecília Zavaglia
Pages
489-492
DOI
10.4028/www.scientific.net/KEM.396-398.489
Citation
H. E. Romeo, M. A. Fanovich, "TTCP-DCPA Based Calcium Phosphate Cements Containing Hybrid Microparticles as Drug Carriers", Key Engineering Materials, Vols. 396-398, pp. 489-492, 2009
Online since
October 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Gabriela A. Silva, Olga P. Coutinho, Paul Ducheyne, I.M. Shapiro, Rui L. Reis
Abstract:Current tissue engineering strategies involve the use of scaffold materials with properties specific for the target tissue. When the tissue...
907
Authors: Tomonori Yoshioka, Toshiyuki Ikoma, Akira Monkawa, Shunji Yunoki, Tetsuya Abe, Masataka Sakane, M. Tanaka
Abstract:Hydroxyapatite (HAp)-alginate gels were developed as drug delivery carriers of the anti-cancer drug, water-insoluble paclitaxel (Taxol). The...
1053
Authors: Daniel Arcos, Adolfo López-Noriega, Eduardo Ruiz-Hernández, Luisa Ruiz, José María González-Calbet, Maria Vallet-Regí
Abstract:Towards the design of bioceramics with control over both macroscopic shape and mesoporosity, silica based mesoporous materials have been...
181
Authors: Hao Wang, Xiu Feng Wang, Cheng Long Yu
Chapter 1: Materials Science and Engineering
Abstract:Poly (aminohexylaminomethyl/phenyl) silsesquioxane (PAHAMPSQ) microparticles with diameter of 350 nm were synthesized by the hydrolytic...
114
Authors: R.P. Félix Lanao, J.W.M. Hoekstra, Joop G.C. Wolke, Sander C.G. Leeuwenburgh, A.S. Plachokova, O.C. Boerman, Jeroen J.J.P. van den Beucken, John A. Jansen
V. In Vivo Study and Clinical Application
Abstract:Periodontitis is one of the most common inflammatory diseases, which can lead to early tooth loss. The conventional treatment of...
300