Paper Title:
Application of New Statistical Approach to Study Drug Release from OCP Coating on Titanium Sheets
  Abstract

In this study, commercially pure titanium (Ti-cp) discs were used as substrates. Octacalcium phosphate (OCP) layers were deposited by immersion of Ti-cp discs up to 7 days into Solution for Bioactivity Evaluation (SBE) and characterized by SEM-EDS and XRD. The OCP coatings were doped with cephazolin or cefalexin by individual immersion in 300 ppm of each solution for 24 h at room temperature. The non-existence of mathematical models to explain drug release from these matrixes made the choosing of correct model, a complex process. Five non-linear mathematical methods were employed in order to identify the possible drug release mechanism using Akaike and Bayesian Information Criterion (AIC and BIC respectively) and its derivatives. The best model was Peppas & Sahlin that consider two stages in release: pure diffusion in first stage, and drug dissolution and migration through the porous matrix at second stage.

  Info
Periodical
Key Engineering Materials (Volumes 396-398)
Main Theme
Edited by
Marcelo Prado and Cecília Zavaglia
Pages
511-514
DOI
10.4028/www.scientific.net/KEM.396-398.511
Citation
G. Fuentes, E. Peón, Y. Campos, N. López, C. X. Resende, G. D. de Almeida Soares, "Application of New Statistical Approach to Study Drug Release from OCP Coating on Titanium Sheets", Key Engineering Materials, Vols. 396-398, pp. 511-514, 2009
Online since
October 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Mont Kumpugdee-Vollrath, Mario Helmis
Chapter 2: Applied Materials Engineering
Abstract:The aim of this research work was to develop the controlled release of two model drugs i.e. water insoluble drug - resveratrol and water...
330
Authors: Noppadol Chongcherdsak, Direk Aekthammarat, Chutima Limmatvapirat, Sontaya Limmatvapirat
II. Bio-materials and Biomimetic Materials
Abstract:The aim of this research was to elucidate the factors affecting drug release and buoyancy properties of effervescent shellac based matrix...
135
Authors: Yong Huang, Zhi De Zhou, Jin Tao Liang, Gui Yin Li
Chapter 1: Applied Materials Engineering
Abstract:In this study, chelerythrine nanoparticles composed of magnetic multiwalled carbon nanotubes (Fe3O4/MWNTs-CHE) were...
127