Paper Title:
Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling
  Abstract

Spherical porous calcium phosphate pellets were fabricated by high shear wet granulation using native starch as a binder. After a heat treatment to eliminate the organic template, pellets were loaded with ibuprofen by solvent evaporation method. In vitro drug release kinetics was determined using an USP II apparatus (Prolabo Dissolution Tester, France). Results showed the interest of the calcination and of the increase in the binder-porogen content, to improve the drug loading (higher drug content) and prolong the release of the drug substance.

  Info
Periodical
Key Engineering Materials (Volumes 396-398)
Main Theme
Edited by
Marcelo Prado and Cecília Zavaglia
Pages
535-538
DOI
10.4028/www.scientific.net/KEM.396-398.535
Citation
M. Viana, A. Désiré, E. Chevalier, E. Champion, R. Chotard-Ghodsnia, D. Chulia, "Interest of High Shear Wet Granulation to Produce Drug Loaded Porous Calcium Phosphate Pellets for Bone Filling", Key Engineering Materials, Vols. 396-398, pp. 535-538, 2009
Online since
October 2008
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Price
$32.00
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