Paper Title:

Effect of Hydroxyapatite on Biodegradable Scaffolds Fabricated by SLS

Periodical Key Engineering Materials (Volumes 396 - 398)
Main Theme Bioceramics 21
Edited by Marcelo Prado and Cecília Zavaglia
Pages 659-662
DOI 10.4028/www.scientific.net/KEM.396-398.659
Citation Szilvia Eosoly et al., 2008, Key Engineering Materials, 396-398, 659
Online since October, 2008
Authors Szilvia Eosoly, Stefan Lohfeld, Dermot Brabazon
Keywords Bone Scaffold, Hydroxyapatite (HAP), Poly(ε-caprolactone), Selective Laser Sintering (SLS)
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Selective laser sintering (SLS) has the potential to fabricate bioresorbable polymer / ceramic composite scaffolds with pre-designed external and internal architecture that can be used for bone tissue engineering applications. Scaffolds were fabricated using poly-ε-caprolactone as the base material. The effect of 15 and 30 wt% of hydroxyapatite (HA) addition was investigated in terms of compressive properties, accuracy, surface topology, and wettability. Fabricated dimensions of PCL microstructures showed great deviations from their nominal values. Average surface roughness was found to be Ra=25±4 µm. Increased HA content had no statistically significant effect on accuracy and surface roughness. However the addition of HA had a significant influence on compressive properties, hydrophobicity and wettability of the samples. Addition of 30 wt% HA improved initial compressive modulus of pure PCL scaffolds from 1.31±0.08 MPa to 1.58±0.18 MPa. Yield strength values increased from 0.14±0.07 MPa to 0.17±0.01 MPa by adding 15 wt% of HA, but decreased with further HA addition. Yield strain for all compositions was over ε=0.06. Increased HA content decreased hydrophobicity and increased wettability of scaffold surfaces. The study demonstrated the ability of SLS to fabricate tissue engineering scaffolds, and the positive effect of HA particle reinforcement in terms of compressive mechanical properties and surface characteristics

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