Paper Title:
Porous Alumina Scaffolds with Bioactive Coating: Implants in the Rat Tibia and In Vitro Studies
  Abstract

Ceramic scaffolds, mechanically qualified, highly porous, non biodegradable and with bioactive coating have been manufactured. The aim of this study was evaluated mechanical and in vivo responses of the porous alumina scaffolds with bioactive coating. The bioactive coating was performed under vacuum with bio-glass (45S5®)) and hydroxyapatite (HAp). Alumina ceramics (Al2O3) are used for bone implants in function of the biocompatibility and the high mechanical reliability of this material. Unfavourably alumina is a bioinert material and bone ingrowths are hard to occur and any implant anchorage becomes difficult. To improve this, ceramic scaffold samples were made with porosity concentration around 75vol% and with average pores diameters around 190.0µm. They were mechanically characterized through macro and micro structural analyses and mechanical tests and biologically through cell culture tests with fibroblastic VERO cell line for cytotoxicity and animal experiments on tibiae rats – Rattus norvegiicus albinos – aiming histological and line scan analysis in order to check the scaffold-bone cellular interaction. Current results seem to suggest the promising properties of the bioactive coated alumina ceramic scaffolds tested. The concentration of 75vol% alumina showed to be the great alternative for an economical solution for porous alumina ceramic scaffolds related to the mechanical properties and bone integration.

  Info
Periodical
Key Engineering Materials (Volumes 396-398)
Main Theme
Edited by
Marcelo Prado and Cecília Zavaglia
Pages
699-702
DOI
10.4028/www.scientific.net/KEM.396-398.699
Citation
C. C. Camilo, C.A. Fortulan, N.A. Parizotto, B. de M. Purquerio, "Porous Alumina Scaffolds with Bioactive Coating: Implants in the Rat Tibia and In Vitro Studies", Key Engineering Materials, Vols. 396-398, pp. 699-702, 2009
Online since
October 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Naoshi Ozawa, Yoshihiro Ideta, Keiko Shimizu, Takeshi Yao
67
Authors: C. Ghiţulica, Ecaterina Andronescu, G. Dumitru, Stefania Stoleriu
2247
Authors: Isabel M. Martins, Claudino Xavier, Maria Helena Mendonça, Manuela Oliveira
Abstract:Previous studies had shown that a promising material could be obtained by mixing aluminium-rich sludge with slate powder (with Al2O3:SiO2...
1695
Authors: Won Seung Cho, Yeon Chul Yoo, Chin Myung Whang, Nam Hee Cho, Woon Suk Hwang, Jun Gyu Kim, Young Jae Kwon
Abstract:Porous alumina bodies were successfully prepared by spark plasma sintering of alumina powders with different amounts of graphite, and by...
1056
Authors: Kozue Matsukawa, Masamitsu Imai, Toyohiko Yano
Abstract:Monazite(LaPO4)-coated alumina-fiber/alumina-YAG (Y3Al5O12) matrix composites were fabricated by in-situ coating of monazite followed by...
213