Paper Title:
Biological Response to Wollastonite Doped α-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats
  Abstract

The biological response following subcutaneous and bone implantation of β-wollastonite(β-W)-doped α-tricalcium phosphate bioceramics in rats was evaluated. Tested materials were: tricalcium phosphate (TCP), consisting of a mixture of α- and β-polymorphs; TCP doped with 5 wt. % of β-W (TCP5W), composed of α-TCP as only crystalline phase; and TCP doped with 15 wt. % of β-W (TCP15), containing crystalline α-TCP and β-W. Cylinders of 2x1 mm were implanted in tibiae and backs of adult male Rattus norvegicus, Holtzman rats. After 7, 30 and 120 days, animals were sacrificed and the tissue blocks containing the implants were excised, fixed and processed for histological examination. TCP, TCP5W and TCP15W implants were biocompatible but neither bioactive nor biodegradable in rat subcutaneous tissue. They were not osteoinductive in connective tissue either. However, in rat bone tissue β-W-doped α-TCP implants (TCP5W and TCP15W) were bioactive, biodegradable and osteoconductive. The rates of biodegradation and new bone formation observed for TCP5W and TCP15W implants in rat bone tissue were greater than for non-doped TCP.

  Info
Periodical
Key Engineering Materials (Volumes 396-398)
Main Theme
Edited by
Marcelo Prado and Cecília Zavaglia
Pages
7-10
DOI
10.4028/www.scientific.net/KEM.396-398.7
Citation
A. M. Minarelli Gaspar, S. Saska, R. García Carrodeguas, A.H. De Aza, P. Pena, P.N. De Aza, S. De Aza, "Biological Response to Wollastonite Doped α-Tricalcium Phosphate Implants in Hard and Soft Tissues in Rats", Key Engineering Materials, Vols. 396-398, pp. 7-10, 2009
Online since
October 2008
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Konstantin Vassilevski, J. Hedley, Alton B. Horsfall, C. Mark Johnson, Nicolas G. Wright
925
Authors: Wen Zhuang Lu, Dun Wen Zuo, Min Wang, Feng Xu, Xiang Feng Li
Abstract:Chemical vapor deposition (CVD) diamond is known for its superior characteristics such as hardness, toughness and wear resistance. However,...
464
Authors: Uraiwan Intatha, Sukum Eitssayeam, Kamonpan Pengpat, Gobwute Rujijanagul, Tawee Tunkasiri
Abstract:In this work, preparation conditions and effect of ZrO2 doped BaFe0.5Nb0.5O3 ceramics were studied. Relationship between structure and...
889
Authors: Xu Li, Li Guan, Chong Liu, Feng Cong, Zhi Ping Yang
Abstract:In this study, a novel green phosphor Ca2SrAl2O6:Ce3+,Tb3+ were prepared by solid state method. The crystal structure and particle morphology...
1823
Authors: Li Xia Ma, Zhi Qiang Fei, Chuan Dong Wang, Yang Liu, Xu Du, Qin Wang
Chapter 8: Biomaterials, Biotechnology and Biochemistry
Abstract:A series praziquantel-loaded poly(lactide-co-glycolide) implants are prepared by melt extrusion. The morphologies, structures and the in...
915