The extrusion process provides conditions for non-uniform metal flow depending on strain, strain rate and temperature of deformation as well as deformation zone geometry. As a result of these conditions significant microstructure gradients are present within the extrudate. The extreme case of the microstructure gradient is a formation of the peripheral coarse grain structure (PCG). This phenomenon is present in many structural aluminum alloys extrudates and its presence should be eliminated or at least significantly reduced because of the mechanical properties and aesthetic points of view. A number of experiments, including physical and numerical simulations, were performed in order to understand and model the origin of the PCG in indirect extrusion of 6xxx alloys. These experiments included different alloy chemistry, various temperatures, extrusion ratios and extrusion speeds allowing analysis of their influence. Parallel to the experimental results the numerical simulation of the metal flow showing the origin of the metal in different extrudate location was performed using software package DEFORM TM. A review of performed research will be followed by the analysis of the results and discussion of future needs.