This study selected three types of organic substance as the main components of high-efficient organic grinding liquid for grinding ceramics with silicon. The grinding efficiency test was conducted on the basis of self-developed grinding mechanism and the findings indicated that the grinding performance of all these three types of grinding liquid were better than average grinding liquid. With Si3N4 Ceramics as the representative test material, the grinding efficiency can be increased at least 1.37 times and more than twice with the grinding fluid prepared with oleic acid or oleic alcohol. The analysis of liquid-solid interface with the help of infrared spectrum showed that there existed abnormal vibration peaks in the liquid-solid interface between Si3N4 ceramics and grinding liquid with (organic substances)–OOH and －OH under normal temperature, which resulted from the adsorption effect of hydrogen bond generated between organic molecule and Si3N4 ceramics. Under high grinding temperature, the friction chemical reaction took place as the result of the absorption effect and the resultant could not only reduce the surface hardness, but also improve the lubricating effect, thus improving the grinding efficiency and surface quality.