The precursor of Ca2Co2O5 was prepared by coprecipitation method. The bulk Ca2Co2O5 samples were prepared by conventional sintering and Spark Plasma Sintering (SPS), respectively. The relative density of bulk Ca2Co2O5 ceramic, which was prepared by conventional sintering is about 75%; while the samples prepared by SPS has a density of 98%. The thermoelectric properties were enhanced by SPS, compared with samples prepared with conventional sintering. The maximum powerfactor of the conventional sintering and SPS samples are 2.70×10-4W∙m-1∙K-2 and 3.85×10-4 W∙m-1∙K-2, respectively.