Cr-doped Y3ScxAl(5-x)O12(Nd:YSAG) powder have been prepared with a combustion method. The powders are nanosized and a pure cubic phase when calcined at 900°C. Transparent Cr:YSAG ceramics were successfully fabricated by sintering the powder compact at 1800°C under H2 atmosphere. The optical properties were investigated in detail. It was found that after Sc substitute for Al, the The octahedral crystal-field parameter Dq and Dq/B was reduced, and that is why the absorption peak move to the longer wavelength side but the emission peak not moved.