The Anti-synchronization of chaotic systems with uncertainty by sliding mode control is studied. Using the principle of poles assignment method, the switching function is designed to guarantee Anti-synchronization of slide mode with nonlinearity terms. Using exponent hitting condition of sliding mode, a robust anti-synchronization controller is proposed. In contrast to the previous works, sliding mode of this controller is free from the influence of disturbance, and the system has both better robustness and quick tracking. Therefore the computation is simple and the conservation is smaller. Finally, Simulation results verify the effectiveness of the proposed scheme.