A new kind design scheme of sensing system for tire pressure monitoring system was introduced in this paper. In order to measure the condition of the tire in real time, MCU, MEMS sensor, thermometer, and wireless communication technology is used in this new system. The MEMS sensor and RF emitter was directly installed in tire. It was transmitted for receiver installed in cab by wireless after gas pressure data gathered. It sensed in time pressure condition by receiver, so that driver adopted corresponding countermeasure. The design of hardware and software is discussed in details.