In dye-sensitized solar cells (DSC), large-size particles in photoanodes can act as light-scattering center to enhance light harvesting efficiency. In this study, macroporous secondary TiO2 particles were prepared by a spray drying method and were introduced to DSC. A few kinds of layered structures were fabricated as photoanodes to evaluate effects of macroporous particles. It was found that open circuit voltage increased due to the presence of macroporous particles. A photoanode composed of stacked nanoparticles and macroporous particles showed better cell performance.