Flow field design has several functions that should perform simultaneously. Therefore, specific plate materials and channel designs are needed to enhance the performance of proton exchange membrane (PEM) fuel cell. Serpentine flow field design is one of the most popular channel configurations for PEM fuel cell system. Some configurations have been developed to improve the cell performance. This paper presents a review on serpentine flow field (SFF) design and its influence to PEM fuel cell performance based on some indicators of performance. The comparisons of SFF with other flow field designs are summarized. The results of some experimental and numerical investigations are also presented.