Paper Title:
Biodegradable Microfluidic Device: Hydrolysis, Decomposition and Surface Modification
  Abstract

Poly(lactic acid) (PLA) is a biodegradable and biocompatible aliphatic polyester whose lactic acid monomers are derived from renewable resources such as corn and sugar beet. As a thermal plastic it can be processed through compounding and injection. As such, we have developed a microfludic device using PLA aimed at blood dialysis application. To quantify the degradation of PLA, its hydrolysis at different pH value was studied. To study the bioresorbable property of these fabricated devices, its decomposition was tested by morphology observation and weight change measurements after embedding in soil under simulated environmental conditions. Upon contact with a hydrophobic surface, platelets and prothrombin are always activated to attach to the surface, resulting in blood clot. This would block the blood flow through the dialysis channels in the microfluidic device. To improve the hydrophilicity, hence the blood compatibility, chemical grafting of a hydrophilic polymer, poly(ethylene oxide) methacrylate (PEGmA), onto the surface of PLA microfluidic device was carried out and the changes in hydrophilicity was monitored through measuring the water contact angle. Our results indicate that chemical grafting of PEGmA significantly improves the hydrophilicity of the device surface.

  Info
Periodical
Key Engineering Materials (Volumes 447-448)
Edited by
Jianhong Zhao, Masanori Kunieda, Guilin Yang and Xue-Ming Yuan
Pages
755-759
DOI
10.4028/www.scientific.net/KEM.447-448.755
Citation
J. E. Low, W. X. Koh, J. K. Lai, Y. J. Lee, X. Li, G. Chen, Y. K. Juay, J. H. Zhao, "Biodegradable Microfluidic Device: Hydrolysis, Decomposition and Surface Modification", Key Engineering Materials, Vols. 447-448, pp. 755-759, 2010
Online since
September 2010
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Qing Hua Tang, Yong Shuai Ma, Dong Zhang
Abstract:The effects of different temperatures on catalytic hydrolysis of polyethylene terephthalate(PET) by zinc sulfate as a catalyst under...
1628
Authors: Ying Fu, Yi Feng Zhang
Abstract:Organic modifier (PSFD) of poly-silicic-ferric (PSF) coagulant was prepared by adding dimethyldiallylammonium chloride (DMDAAC) as additives...
17
Authors: Yong Zhang, Guo Xin Xue, Xiu Mei Zhang, Yan Jun Tang
Abstract:In this work a study on the feasibility of extracting cellulose nanofibers from bamboo fibers, by means of three different procedures was...
759
Authors: Zhi Yong Hu
Chapter 5: Inorganic and Materials
Abstract:Titanium dioxide is an important inorganic chemical product, and low iron and rich titanium slag can be made into titanium dioxide. In this...
682
Authors: Wan Nasrin Afifa Wan Daud, Abdul Aziz Ishak, Syafiza Abd Hashib, Miradatul Najwa Muhd Rodhi
Chapter II: Bio and Chemical Engineering Materials, Technologies and Applications
Abstract:In this study, L(+)-lactic acid (LLA) from cassava fermentation by Rhizopus oryzae NRRL 395 was used as monomer in...
523