To investigate the influence of pressure on densification behavior of metal powder under hot isostatic pressing (HIP), the consolidation of Ti6Al4V powder at various applied pressures during HIP processes were investigated by finite element method in this paper. The plasticity and creep phenomenon of the compact under high temperature and pressure were described by the viscoplastic Perzyna model, which integrated with a modified yield criterion for porous metal materials. The thermo-mechanical coupling analysis was carried out by the finite element code MSC.Marc. The calculated results show non-uniform density distributions for the compact, but this phenomenon decreases as increasing the applied pressure. The densification rate is significantly influenced by applied pressure. The consolidation mechanisms for powder compact were also discussed.