A 5-axis parallel-serial machine tool is proposed, which consists of a 3-DOF parallel mechanism and a 2-DOF serial mechanism, and the kinematics analysis is discussed in detail based on the vector method. The size of the velocity transformation matrix is decreased. The problem of parameter coupling is resolved by adopting identity matrix and four-element vector. The relationship between the velocity and acceleration of the movable platform and the input parameters of the parallel mechanism is established. These algorithms are verified correct through ADAMS (Automatic Dynamic Analysis of Mechanical System) and can be referenced by kinematics analysis, dynamics analysis of parallel or parallel-serial machine tools, which have coupling kinematics parameters.