Adhesive joints are widely used as the joints with the same or different adherents, such as in engineering and electric devices. However, because of mismatch of different materials properties, failures due to crack initiation and propagation are often observed on the interface between adhesive and adherents. Therefore, it is important to analyze stress intensity factor of crack on the interface. In this paper, the effect of material combination of adhesive and adherents on stress intensity factor and effect of the thickness of adhesive on stress intensity factor are discussed. A useful method to calculate the stress intensity factor of interface crack is presented with focusing on the stresses at the crack tip calculated by finite element method. The stress intensity factors are indicated in charts under different thickness of adhesive . It is found that the intensity of singular stress first increases with increasing , then decreases from about , and keeps constant from about , when is the width of adhesive. These results are helpful to design dimensions of devices and choose appropriate materials when adhesives are used inside of them.