In order to realize rapid design, a parametric intelligent design system of picking manipulator (PIDS-PM) of 4 DOF( Degree of Freedom) was developed. The design was reused and became more standard, the development cycle was shortened and the cost was reduced. First, knowledge attribute properties of manipulator were extracted and classified and parameterized according to its functions. They were consisted of a reusable knowledge structure module which included all the information, relationships and maps among parameters. Second, a knowledge repository based on database was constructed, which was used to query the database and obtain the optimal design scheme. Finally, the system was realized by using VC++6.0 including its structure, main function modules, user interface and its design result.