Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers

Maki, Yasuyuki; Dobashi, Toshiaki; Quynh, Tran Minh; Yoneyama, Masaru; Nagasawa, Naotsugu

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Structural Analysis of Rf Sputtered Er Doped Ta₂O₅ Films, p.32
Preparation of CaTiO₃:Pr Phosphor by Using CaB₂O₄ as a Flux, p.38
Solvent-Free Synthesis of Siloxanes and their Usage as Potential Cross-Coupling Reagents, p.43
Preparation of Anisotropic Chitosan Hydrogel with Birefringence and Analysis of Gel Formation Process, p.48
Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers, p.51
Nano-Platelet Structure of Clay Materials Observed by Atomic Force Microscope, p.57
Synthesis and Properties of Fluorescent Biological Molecules Labeled with Novel Silylated Perylene Derivative, p.63
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Paper Title:

Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers

Periodical	Key Engineering Materials (Volume 459)
Main Theme	Silicon Science and Advanced Micro-Device Engineering I
Edited by	Osamu Hanaizumi and Masafumi Unno
Pages	51-56
DOI	10.4028/www.scientific.net/KEM.459.51
Citation	Tran Minh Quynh et al., 2010, Key Engineering Materials, 459, 51
Online since	December, 2010
Authors	Tran Minh Quynh, Masaru Yoneyama, Yasuyuki Maki, Naotsugu Nagasawa, Toshiaki Dobashi
Keywords	Graft Copolymer, PLLA-g-P(NIPAM-co-HEMA), Point Cloud, Thermosensitive Micelle
Price	US$ 28,-

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Abstract

Different poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) copolymers (P(NIPAM-co-HEMA)) were synthesized from N-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) comonomers by both radical and radiation polymerizations for comparison. PLLA-g-P(NIPAM-co-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-co-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-co-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.