Paper Title:
Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers
  Abstract

Different poly(N-isopropylacrylamide-co-hydroxyethyl methacrylate) copolymers (P(NIPAM-co-HEMA)) were synthesized from N-isopropylacrylamide (NIPA) and hydroxyethyl methacrylate (HEMA) comonomers by both radical and radiation polymerizations for comparison. PLLA-g-P(NIPAM-co-HEMA) graft copolymers were synthesized from L-lactide and respective P(NIPAM-co-HEMA) copolymers by ring opening polymerization. Both NMR and FTIR analyses demonstrated the PLLA chains have been grafted on to the P(NIPAM-co-HEMA) backbone. These graft copolymers revealed the cloud point temperature higher than that of PNIPAM homopolymer as determined by optical transmittance. The graft copolymers self-assembled into micelles with regularly spherical structures as observed by atomic force microscopy (AFM). The properties of these graft copolymers are interesting for the drug delivery system.

  Info
Periodical
Edited by
Osamu Hanaizumi and Masafumi Unno
Pages
51-56
DOI
10.4028/www.scientific.net/KEM.459.51
Citation
T. M. Quynh, M. Yoneyama, Y. Maki, N. Nagasawa, T. Dobashi, "Thermosensitive Micelles Composed of Poly(lactide)-g-Poly(NIPAM-co-HEMA) Graft Copolymers", Key Engineering Materials, Vol. 459, pp. 51-56, 2011
Online since
December 2010
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