With the growing population of using public network, network intrusion events happened more frequently. Aim to the drawbacks of traditional information security methods, the multi-agent system model was proved to be very promising. This paper proposes a dynamic distributed information security system based on multi-agent that dynamically integrates all distributed information security facilities to achieve efficiently collaborative information security. In order to validate this proposed approach, the authors give the material experiment test in the end of this paper. The final experiment result suggests that, this proposed approach is feasible, correct and valid.