The conservation of historic stone buildings and sculptures is receiving growing attention from many fields because of increasing bad weathering. At present, special attentions are paid to development of new protective materials. In this paper, we review that some findings of crude protective film of biomimetic materials on the historic stone buildings and sculptures, discuss their biological origin, and propose an approach to prepare the protective agents through the biomimetic method. Moreover, an overview of the Principle of biomineraliztion and biomimetics syntheses is provided. Thus, it is dedicated that the biomimetic synthesis should have great potentialities in applied protective methods and should represent a new prospective in stone conservation.