This article studies the effect of Uyghur sand therapy on rabbit femur bending mechanics. Methods: Papain was injected into the joint space of right knee of 20 male rabbits. The Paptain injected rabbits were divided into two different groups: sand therapy group and control group. The control group rabbits weren’t interfered in any way. The sand therapy group rabbits were given sand therapy for 30 minutes each day for 15 days. On the 16th day, the femur of each rabbit was taken as specimen. The specimen was given the tree-point bending test and the load-deflection curves were obtained. Then Finite Element Ansys method was used to analyze the stress cloud and the deformation cloud; Results:. Damage occurred in the position where the first maximum main stress was given; the form of damage was a brittle fracture. However, the position which corresponds to the maximum bending compressive stress has not been damaged. Finite Element Ansys analysis also showed a similar result. Conclusion: Sand therapy can improve femur bending strength and toughness.