Fiber Reinforced Polymer (FRP) has been effectively used for strengthening concrete beams. In this study, nonlinear finite element (FE) model of the beam strengthened with CFRP is established to analyze the debonding failure caused by the adhesive hollow defects. The constitutive relationship of the adhesive layer in the FE models is similar to Monti’s bi-linear mode. Three different locations of the hollows are considered in the FE models. The principal stresses in the concrete, the debonding stresses in the adhesive and the stress in CFRP are calculated. The results show that the effect of the locations of the hollow is marginal on the principal stresses in the concrete. When the hollow appears close to the interfacial end, the debonding stresses in the adhesive and the shear stress in the CFRP are significant, which easily causes the debonding failure.