The spinel growth induces undulation of the thermal growth oxide layer and decreases the service life of plasma-sprayed thermal barrier coatings. An analytical model is introduced to investigate the effect of spinel growth on the delamination of thermal barrier coating. The analytical results show that the number per unit area and the growth rate of spinel have significant influence on the delamination of thermal barrier coating. The stiffer and thicker thermal barrier coating is more easily to delaminate from the bond coat due to the existence of spinels. The effect of spinel on the delamination cannot be neglected. How to reduce the growth rate and the number of spinel is a key problem to prolong the service life of thermal barrier coatings.