The present paper is an experimental investigation on the machinability of powder metallurgy (PM) nickel-based superalloy during drilling using high-speed steel (M42) drills. The effect of machining parameters on the cutting force, cutting temperature and tool wear were investigated during the experimentation. The effect of machining parameters on the tool wear was examined through SEM micrographs. The research work findings will also provide useful economic machining solution by utilizing economical high-speed steel drills during drilling processing of powder metallurgy nickel-based superalloy, which is otherwise usually machined by costly coated carbide tools or CBN tools. The present approach and results will be helpful for understanding the machinability of powder metallurgy nickel-based superalloy during drilling for the manufacturing engineers.