In this paper, an experiment of fatigue crack propagation in 7050 aluminum alloy was presented. Laser shock processing (LSP) is used to shock the crack surface. Compared with the specimen without LSP, the fatigue life after LSP increased greatly. The simulation of the fatigue crack growth in 7050 aluminum alloy is implemented in FRANC2D. Simulating result is in accordance with the result of the experiment well. Laser shock processing increases the fatigue life and reduce fatigue crack growth rate, it has good prospect on the study of crack arrestment.