Paper Title:
Carboxymethyl Chitosan Nonwoven Scaffold for Bone Regeneration
  Abstract

Natural bone is a composite mainly made from nano/micro-structure of hydroxyapatite and collagen fibers. For bone regeneration by tissue engineering, it is important to synthesize three dimension nano-composites with good biocompatibility, high bioactivity and great bonding property as potentially useful scaffold. In this study, we fabricated chitosan nano-nonwoven scaffold via electrospinning and modified chitosan scaffolds by carboxymethylation (CM) to improve the osteoconductive characteristics. Results of FTIR confirmed the existence of carboxymethyl groups of CMChitosan. Moreover by employed mice osteoblast (MC3T3-E1) cell for adhesion, proliferation and differentiation assays, we found that CMChitosan appeared to have effect on the late stages of osteoblast behavior (calcium deposit).

  Info
Periodical
Edited by
Long Chen, Yongkang Zhang, Aixing Feng, Zhenying Xu, Boquan Li and Han Shen
Pages
712-716
DOI
10.4028/www.scientific.net/KEM.464.712
Citation
X. X. Bao, A. Teramoto, K. Abe, "Carboxymethyl Chitosan Nonwoven Scaffold for Bone Regeneration", Key Engineering Materials, Vol. 464, pp. 712-716, 2011
Online since
January 2011
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Price
$32.00
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