This purpose of the study is to develop the usage intention model of E-Learning systems. A survey of 1071 samples of six teaching hospitals in Taiwan shows that the effects of organizational support and self efficacy on usage intention are mediated by perceived ease of use and perceived useful. According to the statistical results, the proposed model fits very well for the samples. Besides, both organizational support and self efficacy are important antecedents of perceived ease of use and perceived useful. In addition, perceived ease of use has the most influence on usage intention, followed by perceived useful, organizational support, and self efficacy. Further investigation reveals that organizational support and self efficacy have both direct and indirect influences on usage intention. This research can provide E-Learning designers and managers of the hospital with the implication that we must focus not only on the technological aspect (perceived ease of use and perceived useful), but also on the social psychological aspect (organizational support and self efficacy).