One of the most effective methods of manufacturing conical parts is the hydroforming process. The pressure profile during forming is the most important factor on wrinkling, thinning, and punch wall contact. This paper presents a methodology to determine the optimal profile of hydraulic pressure during hydroforming of conical parts. The objective is to minimize the variation of the thickness throughout the part. Initially, the finite element model is developed and verified. The part being modeled is then subjected to different pressure profiles to examine the effect of each profile on thinning. The Response Surface Modeling (RSM) along with Genetic Algorithm (GA) is employed to obtain the optimum pressure profile. The paper describes the methodology developed and reports the results obtained.