In this paper, a spherical fragment penetrating to square honeycomb sandwich plate and solid plate which has the same mass as sandwich plate are simulated by LS-DYNA code. The fragment impacts plates at normal incidence and oblique incidence with 30º impact angle at the velocity of 300m/s, 350m/s, 380m/s, 400m/s, 450m/s and 500m/s separately. And the damage pattern of sandwich plate, the acceleration of fragment and the energy absorption of sandwich plate are acquired. For sandwich plate, the acceleration of fragment is less than that of solid plate and the internal energy absorbed is larger that that of solid plate. The result can be used to design new active fragment to improve the damage effect to sandwich plate.