Non-uniformity of infrared focal plane arrays (IRFPA) decreases the quality of the infrared imaging system greatly, so it is necessary to correct non-uniformity. Now the scene-based correction is being the focus of the study at home and abroad. Firstly, researching on normalized BP artificial neural network correction method in this paper, and then building a SOPC system on Altera's Stratix II EP2S60 DSP Development Board to realize the normalized BP real-time correction non-uniformity. The simulation results show that the SOPC system would meet the requirements of real-time correction. At the same time, the other method could be better to upgrade.