The Fiber Reinforced Plastic (FRP) has been widely used in aircraft, spacecraft, watercraft and transportation because of its excellent mechanical characteristics. The fatigue characteristic of the composite laminate of FRP is important guarantee to the structure security and reliability. In this paper, according to the damage mechanical theory, a fatigue damage accumulation model based on stiffness degradation and the corresponding method of fatigue life prediction are presented. The composite material of T300/ epoxy-resin with high performance has been investigated. The tension-tension fatigue tests have been conducted on the composite laminates. The fatigue life prediction of the composite material is presented. It shows a good agreement to the experimental and theoretical results.