The automotive body system is not only a source for directly radiating noise into the vehicle interior space, but also a key component for transmitting various vibrations and noise. The optimization of the modes for body-in-white has significant meanings for improving the reliability and NVH (Noise, Vibration and Harshness) performance of the whole vehicle. Based on the current situation that there is more severe interior vibration and noise problem occurring in driving for a light passenger vehicle, a hybrid modal analysis method combined with experiment and simulation methods is applied to investigate the vibration and noise characteristics of the whole vehicle body. By performing such modal analysis, the modal frequencies of the auto-body are improved effectively by strengthening the vibration sensitive regions in the body structure. The experiment for measuring interior vibration and noise levels under cruise condition is conducted to validate that the structural optimization for body-in-white has significant contribution for improving the whole vehicle NVH performance.