Evacuation is a process in which threatened people are displaced from dangerous places to safer places in order to reduce the health and life vulnerability of affected people. Constructing typhoon emergency shelters is one of the ways to improve the areas anti-disaster capacity. There are many questions in emigration resettlement work. Such as: the layout of the resettlement places unreasonable, the fixed resettlement is insufficient, temporary resettlement site lacks the necessary living facilities and so on. Planning and construction of emergency shelters is a systematic project, which needs scientific and rational design. This paper proposed a mathematical model applied to the location selection, a solution of genetic algorithm was suggested. Then bring forward a decision-making model for the location-choosing of urgency response system and carried out the design procedure of genetic algorithm to finalize the optimized combination plan.