State education business institutes are believed as catalyst for the economic progress (especial for commerce) of any country. In China, many regional higher education institutes (mainly be regional university) have been founded from 1998. From 2006, most of those regional higher education institutes, such as regional university, promoted to be comprehensive regional higher education institutes (CRHEIs) in succession. Now more andmore students studying in those CRHEIs, and then the quality of teaching should be improved. In this paper, we analyses ICT (Information and communication technology)–based teaching and learning issues at CRHEIs level and old higher education institutes (ORHEs) level. Using normative Delphi method, we discussed ICT-based issues and get that ICT integration in CRHE need to be in lined with proper strategy in order to get their true benefits.