We are interested in a right junction of two plates of different materials (aluminum and copper) placed in contact edge to edge. The aim of this study is the interaction of Lamb waves with a defect located at the junction. The reflection and transmission of the fundamental symmetrical S0 wave is analyzed. The theoretical coefficients of reflection and transmission are obtained by a multi-modal approach based on the orthogonality relations involving different modes. Using the Finite Element Method (FEM), we estimate the limit value of the ratio between the dimension of the defect and the thickness of the structure, for which the multi-modal approach is applicable. In experimental and numerical studies, it is also brought to light the effects of diffraction by the defect.