The grinding experiments on titanium alloy Ti-6Al-4V are conducted with monolayer brazed CBN wheels which are manufactured with rare earth Lanthanum modified Ag-Cu-Ti filler. Grinding force and temperature are measured as well as the topography of wheel surface. Brazed CBN wheels fabricated with Ag-Cu-Ti filler are used for comparison. The results indicate that Lanthanum restrains spread of filler, and keeps the integrity of cutting edges, which increased the sharpness, reduced the grinding force and temperature. Meanwhile, the compounds on the surface of CBN grits are finer and compacter with the addition of Lanthanum, which improves the bonding strength of joint between filler and CBN grits. Lanthanum improves the performance of the brazed CBN wheels while grinding Ti-6Al-4V.